| Manapol® - Why Should I Use It? | | | | cycle and of manosevia the hexose pathway are well |
| "Upon entry to the cells, mannans can activate the | | | | documented and account for Manapol®’s |
| macrophages, enhance cytokine release, stimulate | | | | essential lack of toxicity. Macrophages return to normal |
| macrophage, T- and B-cell interactions and stimulate | | | | when the acetylated mannans are metabolized via the |
| bone arrow activity."1 | | | | hexose-pentose pathway to carbon dioxide and |
| What is Manapol®? | | | | water. In summary, mononuclear cells are capable of |
| Manapol® Powder is a stabilized form of Aloe vera | | | | absorbing acetylated mannans at very high, yet |
| L.(barbadensis miller) gel that ontains a similar ratio of | | | | non-cytotoxic concentrations. If you are taking |
| acetylated mannans (mostly in the form of mannose), | | | | prescription medications or are under the care of a |
| calcium malate, pectins unique to Aloe vera, and other | | | | licensed practitioner, always consult before taking any |
| soluble fibers. Within 24 hours of harvesting the Aloe | | | | dietary supplement. |
| vera L. leaves, Manapol® is freeze-dried into a | | | | How can Manapol® benefit me? |
| powder utilizing a patented alcoholprecipitation method | | | | When taken daily, Manapol® enhances your immune |
| to lock in nature’s freshness and biological activity. | | | | system. An immune system that is modulated will |
| • Certified kosher parve for both growing and | | | | function properly and may help address conditions |
| manufacturing processes. | | | | associated with a suppressed or over stimulated |
| • Aloe certified organically grown by ECO-Logica in | | | | immune system. When compared to other natural |
| Costa Rica. | | | | botanicals and extracts, Manapol® is the least |
| Unlike many related molecules that are broken down | | | | obtrusive choice for your body. |
| within the digestive system and used by the body as | | | | Immune modulators such as the acetylated mannans |
| fuel, the structure for the acetylated mannans or | | | | found in Manapol®, work more to “balance” |
| polysaccharides found in Manapol® prevent it from | | | | the immune system thus allowing it to function properly. |
| being metabolized until it reaches the cell. Amylase, the | | | | How much Manapol® is right for me? |
| only polysaccharide-digesting enzyme that our bodies | | | | To maintain a healthy immune system, adults should |
| produce in the digestive tract, can only break down b | | | | take a minimum of 160 milligrams of Manapol® per |
| linkages, not a-linkages. Therefore, your body digests | | | | day. When responding to a compromised immune |
| a-linked polysaccharides such as corn starch and | | | | system, recommended intake should range between |
| potato starch in the intestinal tract; but digestion of | | | | 300 to 2,000 milligrams per day depending on |
| b-linked polysaccharides such as cellulose or | | | | situation.2 |
| Manapol® occurs at the cellular level in the | | | | References Cited |
| macrophages. Manapol® and other b-linked | | | | 1. Womble D, Helderman JH. |
| molecules are absorbed from the digestive tract | | | | Enhancement of alloresponsivenessof human |
| through an undefined mechanism and are then | | | | lymphocytes by acemannan |
| metabolized intercellularly.2 | | | | (Carrisyn™). Int. J. Immunopharmacol. |
| How does it work? | | | | 1988, 10:967-974. |
| Manapol® contains acetylated mannans primarily in | | | | 2. Pharmacologic effects and mechanismsof action of |
| the form of mannose. Mannose as well as other | | | | Acemannan. Carrington |
| complex carbohydrate polymers have been shown to | | | | Laboratories, Inc. 1992. |
| possess immune modulating activity by binding to | | | | 3. Chinnah AD, Baig M, Tizard IR, et al. |
| macrophage cells via protein receptors.3 Once the | | | | Antigen dependent adjuvant activityof a |
| mannans are attached to the macrophage receptors, | | | | polysdispersed b-(1,4)-linkedacetylated mannan |
| the body’s immune system responds as it would if | | | | (acemannan). |
| it were being activated naturally by foreign substances. | | | | Vaccine. 1992; 10:551-558. |
| This results in macrophage production of tumor | | | | 4. IR Tizard, RH Carpentar, et al. Thebiological activities |
| necrosis factor alpha (TNF-a), interleukin-1 (IL-1), and | | | | of mannans andrelated complex carbohydrates. Mol. |
| interleukin-6 (IL-6) as well as other cytokines and | | | | Biother. 1989; 6(1): 290-296. |
| oxidants. | | | | Manapol® Powder is a registered trademark of |
| Is Manapol® safe? | | | | Carrington Laboratories, Inc. and is protected by U.S. |
| Metabolism of acetic acid (acetate) via the citric acid | | | | Patents Nos. 4,917,890 and 4,959,214. |